SCHEMBL7180682

SCHEMBL7180682

O=C(CCc1ccc2ccccc2c1)Nc1[nH]nc2c1CN(C(=O)NN1CCCCC1)C2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 8/20 0.44
CCNA2 P20248 2/20 0.40
CDK2 P24941 2/20 0.40
CCNA1 P78396 2/20 0.40
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37
FAAH O00519 2/20 0.37
HRH3 Q9Y5N1 1/20 0.36
GSK3A P49840 1/20 0.36
GSK3B P49841 1/20 0.36
ACHE P22303 1/20 0.36
NPY5R Q15761 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2923375 0.86 HCAR2 (0.44) HCAR2CCNA2CDK2CCNA1ALDH1A1
SCHEMBL2948005 0.82 HCAR2 (0.43) HCAR2MEN1ALDH1A1LMNAMAPT
SCHEMBL2924081 0.81 HCAR2 (0.42) HCAR2CCNA2CDK2CCNA1MEN1
SCHEMBL2921852 0.80 CYP2C19 (0.41) HCAR2CCNA2CDK2CCNA1FAAH
SCHEMBL2923940 0.80 HCAR2 (0.41) HCAR2CCNA2CDK2CCNA1MEN1
SCHEMBL2921723 0.79 HTT (0.49) HCAR2MEN1ALDH1A1LMNAMAPT
SCHEMBL2921923 0.78 HCAR2 (0.43) HCAR2CCNA2CDK2CCNA1MEN1
SCHEMBL2916086 0.77 HCAR2 (0.38) HCAR2CCNA2CDK2CCNA1MEN1
SCHEMBL2921211 0.75 CDK2 (0.51) CCNA2CDK2CCNA1MEN1KMT2A
SCHEMBL2922329 0.73 CDK2 (0.50) CCNA2CDK2CCNA1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1320531-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-06-25 EP disclosed
WO-2002012242-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2002-02-14 WO disclosed