Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178167 | 0.90 | HRH4 (0.41) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL7287614 | 0.87 | HRH2 (0.47) | HRH2HRH4 | |
| SCHEMBL7287548 | 0.87 | HRH2 (0.47) | HRH2HRH4 | |
| SCHEMBL7179013 | 0.87 | HRH2 (0.42) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL9865989 | 0.86 | EBP (0.38) | EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL7174497 | 0.85 | HRH4 (0.39) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL9876542 | 0.85 | HRH4 (0.39) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL7175112 | 0.85 | HRH2 (0.38) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL8581370 | 0.85 | HRH4 (0.38) | HRH2EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL9866789 | 0.85 | CYP1A2 (0.38) | HRH2EBPSIGMAR1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0655914-A4 | NOVEL COMPOSITIONS. | NAHOUM CESAR ROBERTO DIAS (BR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0655914-A1 | NOVEL COMPOSITIONS | NAHOUM, Cesar Roberto Dias (BR) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004120-A2 | METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST | NAHOUM CESAR ROBERTO DIAS (BR) | 1994-03-03 | — | — | WO | disclosed |
| US-4013659-A | CERTAIN N,N'-DISUBSTITUTED GUANIDINE COMPOUNDS AND THEIR USE | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-22 | — | — | US | disclosed |