Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722029 | 1.00 | HPGD (0.43) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL4955700 | 0.87 | USP2 (0.43) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL8065805 | 0.84 | CA12 (0.50) | KMT2APOLBSMN1; SMN2CA12CA1 | |
| SCHEMBL8066720 | 0.84 | CA12 (0.50) | KMT2APOLBSMN1; SMN2CA12CA1 | |
| SCHEMBL8065796 | 0.84 | CA12 (0.50) | KMT2APOLBSMN1; SMN2CA12CA1 | |
| SCHEMBL3644471 | 0.80 | HPGD (0.40) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL29869399 | 0.80 | HPGD (0.40) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL248670 | 0.80 | HPGD (0.40) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL1443195 | 0.80 | HPGD (0.40) | HPGDALDH1A1NPC1RAB9AHTT | |
| SCHEMBL698329 | 0.79 | NPC1 (0.51) | HPGDALDH1A1NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311265-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS | Targacept, Inc. (US) | 2003-05-21 | — | — | EP | claimed |
| WO-2002005798-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS | TARGACEPT, INC. (US) | 2002-01-24 | — | — | WO | claimed |