Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.84 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450937 | 0.91 | PTGER4 (1.00) | PTGER4PTGER2MAPK8CYP3A4MAPK14 | |
| SCHEMBL4085505 | 0.89 | PTGER4 (0.77) | PTGER4PTGER2MAPK8LIPGCYP3A4 | |
| Hydrochloric Acid SCHEMBL6908368 | 0.89 | PTGER4 (0.77) | PTGER4PTGER2MAPK8LIPGCYP3A4 | |
| SCHEMBL13954366 | 0.88 | PTGER4 (0.76) | PTGER4PTGER2MAPK8LIPGCYP3A4 | |
| SCHEMBL4448313 | 0.87 | PTGER4 (0.78) | PTGER4PTGER2LIPGKMT2ACYP1A2 | |
| SCHEMBL4087663 | 0.87 | PTGER4 (0.74) | PTGER4PTGER2MAPK8LIPGKMT2A | |
| SCHEMBL4455024 | 0.87 | PTGER4 (0.74) | PTGER4PTGER2LIPGCYP3A4MAPK14 | |
| SCHEMBL4092310 | 0.87 | PTGER4 (0.81) | PTGER4PTGER2LIPGCYP3A4MAPK14 | |
| SCHEMBL4450413 | 0.87 | PTGER4 (0.81) | PTGER4PTGER2LIPGCYP3A4MAPK14 | |
| SCHEMBL6908965 | 0.85 | PTGER4 (0.71) | PTGER4PTGER2LIPGCYP3A4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068234-A1 | NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |