Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182384

SCHEMBL7182384

SCHEMBL7182384

CC(C)(C)Oc1ccc(PC(=O)c2c(Cl)cccc2Cl)cc1.[LiH]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.38
▸ PPARA Q07869 6/20 0.37
▸ CYP1A2 P05177 2/20 0.37
▸ CYP3A4 P08684 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ PPARG P37231 3/20 0.34
▸ LMNA P02545 1/20 0.34
▸ FABP2 P12104 1/20 0.33
▸ SLC22A12 Q96S37 1/20 0.33
▸ ABCB11 O95342 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ HTR2A P28223 1/20 0.33
▸ PMP22 Q01453 1/20 0.33
▸ PTGS2 P35354 1/20 0.33
▸ ACACB O00763 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182840 0.93 TYK2 (0.36) POLBPPARACYP1A2CYP3A4MAPT
SCHEMBL7188962 0.92 CA12 (0.39) POLBMAPTMEN1KMT2AGAA
SCHEMBL7175205 0.85 ACACB (0.33) PPARACYP1A2CYP3A4MAPTMEN1
SCHEMBL7182801 0.83 KMT2A (0.46) POLBMAPTMEN1KMT2AALDH1A1
SCHEMBL7175906 0.83 CA12 (0.42) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL7187567 0.82 MAPK8 (0.35) POLBPPARAMAPTMEN1KMT2A
SCHEMBL7182105 0.81 POLB (0.35) POLBPPARACYP1A2CYP3A4MAPT
SCHEMBL7175924 0.80 POLB (0.37) POLBMAPTALDH1A1LMNAGAA
SCHEMBL7181248 0.80 POLB (0.35) POLBPPARACYP1A2CYP3A4MAPT
SCHEMBL7186881 0.79 POLB (0.43) POLBMAPTMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 POLB 2322/4885PPARA 3039/4885CYP1A2 1595/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 POLB 2993/4885PPARA 2624/4885CYP1A2 2020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.