Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.41 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6711498 | 0.97 | PDE5A (0.41) | PDE5ABCDIN3DPDE11AACHEKDM4E | |
| SCHEMBL6711573 | 0.92 | PDE5A (0.41) | PDE5ABCDIN3DPDE11AACHEKDM4E | |
| SCHEMBL6711294 | 0.91 | PDE5A (0.40) | PDE5ABCDIN3DPDE11AACHEKDM4E | |
| SCHEMBL7096128 | 0.91 | PDE5A (0.43) | PDE5ABCDIN3DPDE11AACHE | |
| SCHEMBL6708165 | 0.90 | PDE5A (0.40) | PDE5ABCDIN3DPDE11AACHEKDM4E | |
| SCHEMBL7186519 | 0.90 | PDE5A (0.42) | PDE5ABCDIN3DPDE11AACHE | |
| SCHEMBL6709546 | 0.90 | KDM4E (0.47) | PDE5APDE11AACHEKDM4EALDH1A1 | |
| SCHEMBL28759761 | 0.88 | PDE11A (0.42) | PDE5APDE11AACHE | |
| SCHEMBL6708334 | 0.87 | KDM4E (0.46) | PDE5APDE11AACHEKDM4EALDH1A1 | |
| SCHEMBL6709442 | 0.87 | PDE5A (0.43) | PDE5ABCDIN3DPDE11AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355649-A2 | PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO 4,3-D]PYRIMIDINE AND NITRATES OR THIENOPYRIMIDINES AND NITRATES | MERCK PATENT GmbH (DE) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002060449-A2 | PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO[4,3-D]PYRIMIDINE AND NITRATES OR THIENOPYRIMIDINES AND NITRATES | MERCK PATENT GMBH (DE) | 2002-08-08 | — | — | WO | disclosed |