Sugi Predict

Sugi Predict / Compounds / SCHEMBL7183728

SCHEMBL7183728

SCHEMBL7183728

Cc1cc(C(C)(C)C)cc(C)c1C(=O)Pc1ccc(Oc2ccccc2)cc1.[LiH]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRD5A2 P31213 1/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ PPARG P37231 3/20 0.38
▸ RAF1 P04049 2/20 0.38
▸ MAPT P10636 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ PPARA Q07869 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ PTGS1 P23219 1/20 0.37
▸ LTA4H P09960 1/20 0.37
▸ NR1H2 P55055 1/20 0.37
▸ BAX Q07812 1/20 0.37
▸ CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7177267 0.88 SRD5A2 (0.41) SRD5A2NPC1RAB9AMEN1KMT2A
SCHEMBL7180014 0.87 RXRB (0.39) L3MBTL1KMT2AALDH1A1LMNAPPARG
SCHEMBL7180151 0.86 RAF1 (0.40) SRD5A2L3MBTL1NPC1RAB9AMEN1
SCHEMBL7181237 0.85 MAPT (0.43) L3MBTL1NPC1RAB9AMEN1KMT2A
SCHEMBL7188184 0.85 RXRB (0.42) LMNAMAPTCYP2C9
SCHEMBL7180835 0.85 MEN1 (0.43) SRD5A2L3MBTL1NPC1RAB9AMEN1
SCHEMBL7174868 0.84 RAF1 (0.37) SRD5A2L3MBTL1NPC1RAB9AMEN1
SCHEMBL7186707 0.84 NR4A2 (0.50) L3MBTL1MEN1KMT2ALMNAPPARG
SCHEMBL7175886 0.84 EPHX2 (0.33) L3MBTL1ALDH1A1LMNAPPARGMAPT
SCHEMBL7180880 0.84 KDM4E (0.36) SRD5A2L3MBTL1NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 SRD5A2 15/4885L3MBTL1 302/4885NPC1 772/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 SRD5A2 29/4885L3MBTL1 126/4885NPC1 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.