Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865315 | 0.83 | NPSR1 (0.48) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL1439502 | 0.75 | NPSR1 (0.42) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL3125283 | 0.75 | NPSR1 (0.47) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL18394764 | 0.75 | NPSR1 (0.42) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL4339912 | 0.75 | NPSR1 (0.42) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| Ammonia Solution, Strong SCHEMBL28325233 | 0.73 | NPSR1 (0.45) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL27736443 | 0.73 | CYP19A1 (0.44) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL11908378 | 0.73 | CYP19A1 (0.46) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL4222114 | 0.72 | CYP19A1 (0.43) | NPSR1CYP19A1NAAACYP17A1EPHX2 | |
| SCHEMBL865316 | 0.72 | CYP19A1 (0.43) | NPSR1CYP19A1NAAACYP17A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620789-B1 | Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs | GENENTECH, INC. | 2003-09-16 | — | — | US | disclosed |