Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183989 | 1.00 | ESR1 (0.59) | ESR1ESR2SRD5A2CYP1A1CYP1B1 | |
| SCHEMBL7182549 | 0.93 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7182543 | 0.93 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7186129 | 0.92 | ESR1 (0.61) | ESR1ESR2SRD5A2CYP1A1CYP1B1 | |
| SCHEMBL7186132 | 0.92 | ESR1 (0.61) | ESR1ESR2SRD5A2CYP1A1CYP1B1 | |
| SCHEMBL7190627 | 0.92 | ESR1 (0.52) | ESR1ESR2SRD5A2CYP1A1CYP1B1 | |
| SCHEMBL7190635 | 0.92 | ESR1 (0.52) | ESR1ESR2SRD5A2CYP1A1CYP1B1 | |
| SCHEMBL7189360 | 0.90 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL7189357 | 0.90 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL7195203 | 0.88 | ESR1 (0.58) | ESR1ESR2CYP1A1CYP1B1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |