Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185054 | 1.00 | PTPN1 (0.47) | PTPN1ABCG2CAPN1DPP4NPC1 | |
| SCHEMBL7184692 | 0.88 | CAPN1 (0.51) | PTPN1ABCG2CAPN1DPP4 | |
| SCHEMBL7184694 | 0.88 | CAPN1 (0.51) | PTPN1ABCG2CAPN1DPP4 | |
| SCHEMBL7189977 | 0.87 | PTPN1 (0.47) | PTPN1ABCG2CAPN1DPP4PDE4A | |
| SCHEMBL7189980 | 0.87 | PTPN1 (0.47) | PTPN1ABCG2CAPN1DPP4PDE4A | |
| SCHEMBL7186330 | 0.86 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL7186329 | 0.86 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL9240428 | 0.86 | ABCG2 (0.53) | PTPN1ABCG2DPP4MAPT | |
| SCHEMBL9240426 | 0.86 | ABCG2 (0.53) | PTPN1ABCG2DPP4MAPT | |
| SCHEMBL7180253 | 0.86 | ABCG2 (0.59) | PTPN1ABCG2CAPN1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6603046-B1 | The invention is drawn to novel bis-aromatic a, beta -unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria. | LICA PHARMACEUTICALS A/S (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-0634927-B1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | LICA PHARMACEUTICALS AS (DK) | 2001-07-04 | — | — | EP | disclosed |
| US-5985935-A | PARASITICIDES OR BACTERICIDES | STATENS SERUMINSTITUT (DK) | 1999-11-16 | — | — | US | disclosed |