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SCHEMBL7185593

SCHEMBL7185593

Cc1cc(C)c(C(=O)Pc2ccc(Oc3ccccc3)cc2Oc2ccccc2)c(C)c1C.[LiH]

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 P23219 1/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ SRD5A2 P31213 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ FFAR1 O14842 3/20 0.35
▸ FFAR4 Q5NUL3 1/20 0.35
▸ AKR1C3 P42330 1/20 0.35
▸ XDH P47989 1/20 0.34
▸ PTGS2 P35354 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ NR1H4 Q96RI1 1/20 0.33
▸ DHODH Q02127 1/20 0.33
▸ TTR P02766 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium SCHEMBL7185604 0.98 SRD5A2 (0.36) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7188197 0.90 PTGS1 (0.38) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7182259 0.88 PTGS1 (0.38) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7175874 0.86 MEN1 (0.44) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7179794 0.85 KDM4E (0.36) PTGS1KMT2AMEN1CYP2D6SRD5A2
Lithium SCHEMBL7182271 0.85 SRD5A2 (0.38) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7174868 0.85 RAF1 (0.37) PTGS1KMT2AMEN1CYP2D6SRD5A2
Lithium SCHEMBL7175882 0.84 MEN1 (0.41) PTGS1KMT2AMEN1CYP2D6SRD5A2
SCHEMBL7179657 0.84 SRD5A2 (0.40) PTGS1KMT2AMEN1CYP2D6SRD5A2
Lithium SCHEMBL7174872 0.82 RAF1 (0.37) KMT2AMEN1SRD5A2KDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 PTGS1 3066/4885KMT2A 1586/4885MEN1 2312/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 PTGS1 3435/4885KMT2A 956/4885MEN1 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.