Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.59 |
| ▸ | CASP6 | P55212 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242768 | 0.88 | KDM4E (0.78) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL5245834 | 0.87 | MEN1 (0.77) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL6764894 | 0.87 | KMT2A (0.77) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL6760865 | 0.87 | MEN1 (0.77) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL5245777 | 0.87 | MEN1 (0.77) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL5247282 | 0.85 | MEN1 (0.73) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL8153875 | 0.84 | MAPT (0.71) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL5287286 | 0.84 | MEN1 (0.71) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL6764058 | 0.84 | MEN1 (0.71) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL5291639 | 0.82 | MEN1 (0.69) | MAPTMEN1KMT2AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357915-A2 | PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO 4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062343-A2 | PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2002-08-15 | — | — | WO | claimed |