Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 7/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189519 | 0.88 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL7184758 | 0.88 | ESR1 (0.58) | ESR1ESR2THRBATM | |
| SCHEMBL7184764 | 0.88 | ESR1 (0.58) | ESR1ESR2THRBATM | |
| Water SCHEMBL7184036 | 0.87 | ESR1 (0.57) | ESR1ESR2THRBATM | |
| Water SCHEMBL7184030 | 0.87 | ESR1 (0.57) | ESR1ESR2THRBATM | |
| SCHEMBL7184090 | 0.83 | CYP3A4 (0.52) | ESR1ESR2LMNAMEN1CYP3A4 | |
| SCHEMBL7182557 | 0.83 | ESR1 (0.59) | ESR1ESR2THRBATM | |
| SCHEMBL7182553 | 0.83 | ESR1 (0.59) | ESR1ESR2THRBATM | |
| SCHEMBL7189464 | 0.82 | ESR1 (0.55) | ESR1ESR2THRBATMTUBB4A | |
| SCHEMBL7181393 | 0.82 | ESR1 (0.54) | ESR1ESR2THRBATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |