Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188245 | 1.00 | CYP3A4 (0.40) | CYP3A4CYP2D6PRMT5WDR77DRD4 | |
| SCHEMBL7185752 | 0.91 | CYP3A4 (0.44) | CYP3A4CYP2D6PRMT5WDR77DRD4 | |
| SCHEMBL7185745 | 0.91 | CYP3A4 (0.44) | CYP3A4CYP2D6PRMT5WDR77DRD4 | |
| SCHEMBL7190841 | 0.89 | PDE7A (0.42) | PRMT5WDR77DRD4PDE7APDE7B | |
| SCHEMBL7190835 | 0.89 | PDE7A (0.42) | PRMT5WDR77DRD4PDE7APDE7B | |
| SCHEMBL7190422 | 0.88 | PDE7A (0.49) | PRMT5WDR77HSD11B1PDE7APDE7B | |
| SCHEMBL7190418 | 0.88 | PDE7A (0.49) | PRMT5WDR77HSD11B1PDE7APDE7B | |
| SCHEMBL7190968 | 0.87 | SMN1; SMN2 (0.42) | CYP3A4OPRM1MAPT | |
| SCHEMBL7190975 | 0.87 | SMN1; SMN2 (0.42) | CYP3A4OPRM1MAPT | |
| SCHEMBL7179404 | 0.86 | C5AR1 (0.47) | CYP3A4CYP2D6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |