Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 18/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.39 |
| ▸ | PTPRC | P08575 | 3/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203274 | 0.89 | PTPN1 (0.45) | PTPN1PTPN2PTPRC | |
| SCHEMBL7194760 | 0.86 | PTPN1 (0.44) | PTPN1PTPN2PTPRCPTPN5 | |
| SCHEMBL7203277 | 0.77 | PTPN1 (0.35) | PTPN1PTPN2PTPRC | |
| SCHEMBL7189116 | 0.76 | PTPN1 (0.51) | PTPN1PTPN2PTPRC | |
| SCHEMBL7600045 | 0.75 | PTPN1 (0.48) | PTPN1PTPN2PTPRC | |
| SCHEMBL7194763 | 0.74 | PTPN1 (0.37) | PTPN1PTPN2PTPRC | |
| SCHEMBL7593820 | 0.73 | PTPN1 (0.50) | PTPN1PTPN2PTPRC | |
| SCHEMBL7595283 | 0.73 | PTPN1 (0.48) | PTPN1PTPN2PTPRC | |
| SCHEMBL7188314 | 0.72 | PTPN1 (0.59) | PTPN1PTPN2PTPRCPTPN5 | |
| SCHEMBL7597975 | 0.72 | PTPN1 (0.47) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |