Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.53 |
| ▸ | CA1 | P00915 | 10/20 | 0.39 |
| ▸ | CA2 | P00918 | 10/20 | 0.39 |
| ▸ | CA7 | P43166 | 9/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 9/20 | 0.39 |
| ▸ | CA12 | O43570 | 9/20 | 0.39 |
| ▸ | CA6 | P23280 | 8/20 | 0.39 |
| ▸ | CA9 | Q16790 | 8/20 | 0.39 |
| ▸ | CA4 | P22748 | 7/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 7/20 | 0.39 |
| ▸ | CA3 | P07451 | 5/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 6/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665316 | 0.99 | PTPN1 (0.54) | PTPN1CA1CA2CA7CA13 | |
| SCHEMBL7189721 | 0.98 | PTPN1 (0.53) | PTPN1CA1CA2CA7CA13 | |
| Butane SCHEMBL7183122 | 0.96 | PTPN1 (0.51) | PTPN1CA1CA2CA7CA13 | |
| SCHEMBL7183134 | 0.88 | PTPN1 (0.43) | PTPN1PTPN2PTPN5 | |
| SCHEMBL7190972 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2PTPN5 | |
| SCHEMBL7189715 | 0.80 | PTPN1 (0.34) | PTPN1CA1CA2CA7CA13 | |
| SCHEMBL7665321 | 0.79 | PTPN1 (0.34) | PTPN1CA1CA2CA7CA13 | |
| SCHEMBL7188299 | 0.78 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL7183129 | 0.77 | PTPN1 (0.49) | PTPN1CA1CA2CA7CA13 | |
| SCHEMBL7595310 | 0.75 | PTPN1 (0.64) | PTPN1CA1CA2CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | PTPN1 13/4885CA1 4360/4885CA2 2577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.