Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.61 |
| ▸ | AKT2 | P31751 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.61 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.61 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853348 | 0.88 | AKT1 (0.71) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6855697 | 0.86 | AKT1 (1.00) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6855693 | 0.86 | AKT1 (1.00) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6856050 | 0.76 | AKT1 (1.00) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6857804 | 0.74 | AKT1 (0.55) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6857801 | 0.74 | AKT1 (0.55) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6855412 | 0.74 | AKT1 (1.00) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6855409 | 0.74 | AKT1 (1.00) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL6853355 | 0.74 | AKT1 (0.61) | AKT1ROCK2PIM1RPS6KB1AKT2 | |
| SCHEMBL7185912 | 0.74 | AKT1 (0.81) | AKT1ROCK2PIM1RPS6KB1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |