Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7201925 | 0.93 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7194070 | 0.92 | EDNRA (0.90) | EDNRAEDNRB | |
| SCHEMBL7201930 | 0.90 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL25637066 | 0.89 | EDNRA (0.84) | EDNRAEDNRB | |
| SCHEMBL7196207 | 0.89 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL7194130 | 0.88 | EDNRA (0.82) | EDNRAEDNRB | |
| Avosentan SCHEMBL29379732 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| Avosentan SCHEMBL2742679 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7202003 | 0.87 | EDNRA (0.84) | EDNRAEDNRB | |
| SCHEMBL7196215 | 0.86 | EDNRA (0.75) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596719-B1 | Manufacturing those compounds, pharmaceutical compositions containing one or more of those compounds as endothelin antagonists, and a method of treating a subject having a disorder involving endothelin with the compounds of the | ACTELIO PHARMACEUTICALS LTD. (CH) | 2003-07-22 | — | — | US | disclosed |
| EP-1137642-A1 | BIS-SULFONAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001017976-A1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-03-15 | — | — | WO | disclosed |