Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11606150 | 0.84 | CYP3A4 (0.44) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL251912 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL29528763 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL253023 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL253024 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL251914 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL29528605 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL251913 | 0.83 | CYP3A4 (0.42) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL287535 | 0.82 | CYP2D6 (0.45) | KDM4ELMNAADRA2AHIF1AADRA2C | |
| SCHEMBL5581682 | 0.82 | CYP2D6 (0.45) | KDM4ELMNAADRA2AHIF1AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030026799-A1 | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor | MEDLYTE, INC. | 2003-02-06 | — | — | US | disclosed |
| EP-0842148-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006136-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1997-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030026799-A1 | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor | SPHK1, SGPL1, SGMS1 | KDM4E 4788/4885LMNA 414/4885ADRA2A 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.