Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | PI4KA | P42356 | 3/20 | 0.61 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.61 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | AHCY | P23526 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673251 | 0.84 | EGFR (0.70) | ADORA2AADORA1EGFRPI4KAPI4K2B | |
| SCHEMBL17165347 | 0.81 | EGFR (0.66) | ADORA2AADORA1EGFRPI4KAPI4K2B | |
| SCHEMBL2495370 | 0.80 | ADORA2A (0.69) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1871838 | 0.80 | ADORA2A (0.75) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL27713663 | 0.79 | EGFR (0.64) | ADORA2AADORA1EGFRPI4KAPI4K2B | |
| SCHEMBL11222112 | 0.79 | ADORA2A (0.80) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL12925855 | 0.78 | ADORA2A (0.71) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL27664399 | 0.77 | ADORA2A (0.66) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL3394729 | 0.77 | ADORA2A (0.71) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15841807 | 0.77 | ADORA2A (0.71) | ADORA2AADORA1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030125298-A1 | Cancer therapy comprising deaminase enzyme inhibitors | CTRE DE RECHERCHE INDUST. DU QUEBEC (CA) | 2003-07-03 | — | — | US | disclosed |
| US-6579857-B1 | Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors | EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INSTITUTE | 2003-06-17 | — | — | US | disclosed |
| EP-0936911-B1 | ADENOSINE DEAMINASE INHIBITORS | RHODE ISLAND EDUCATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076524-A1 | COMBINATION CANCER THERAPY COMPRISING ADENOSINE AND DEAMINASE ENZYME INHIBITOR | EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INSTITUTE (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0936911-A4 | — | — | 1999-10-06 | — | — | EP | disclosed |
| CN-1227489-A | Adenosine deaminase inhibitors | GOVERNORS FOR HIGH EDUCATION S (US) | 1999-09-01 | — | — | CN | disclosed |
| EP-0936911-A1 | ADENOSINE DEAMINASE INHIBITORS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0871449-A1 | HYDROXYNONYLADENINE ANALOGS WITH ENHANCED LIPOPHILIC AND ANTI-ISCHEMIC TRAITS | Cypros Pharmaceutical Corporation (US) | 1998-10-21 | — | — | EP | disclosed |
| EP-0871449-A4 | — | — | 1998-10-21 | — | — | EP | disclosed |
| WO-1998002166-A1 | ADENOSINE DEAMINASE INHIBITORS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1998-01-22 | — | — | WO | disclosed |
| US-5703084-A | Adenosine deaminase inhibitors | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1997-12-30 | — | — | US | disclosed |
| WO-1997028803-A1 | HYDROXYNONYLADENINE ANALOGS WITH ENHANCED LIPOPHILIC AND ANTI-ISCHEMIC TRAITS | CYPROS PHARMACEUTICAL CORPORATION (US) | 1997-08-14 | — | — | WO | disclosed |
| US-5491146-A | ADENOSIN DEAMINASE INHIBITORS | CYPROS PHARMACEUTICAL CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |
| US-4315920-A | Adenosine deaminase inhibitors | BURROUGHS WELLCOME CO. (US) | 1982-02-16 | — | — | US | disclosed |