Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 15/20 | 0.51 |
| ▸ | HTR1B | P28222 | 14/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | HTR1F | P30939 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208729 | 0.81 | HTR1D (0.58) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7199556 | 0.80 | HTR1D (0.55) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7489228 | 0.80 | HTR1D (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7484492 | 0.79 | HTR1D (0.60) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7204034 | 0.77 | HTR1D (0.54) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7206450 | 0.77 | HTR1D (0.53) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7205439 | 0.76 | HTR1D (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7201182 | 0.76 | HTR1D (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7488515 | 0.76 | HTR1D (0.72) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7485069 | 0.76 | CYP1A2 (0.68) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |