Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanoxabenz SCHEMBL122726 | 0.94 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanoxabenz SCHEMBL10409620 | 0.94 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL4103258 | 0.85 | POLB (0.57) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL15389 | 0.85 | POLB (0.57) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL6302549 | 0.85 | POLB (0.57) | POLBHTTSLC22A1HTR1AADRA2A | |
| SCHEMBL19449739 | 0.85 | POLB (0.60) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL11685908 | 0.84 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL170112 | 0.84 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL22616212 | 0.84 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A | |
| Guanabenz SCHEMBL22616213 | 0.84 | POLB (0.55) | POLBHTTSLC22A1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599943-B1 | Preventive treatment, related to the radical generating nature of the xanthine dehydrogenase/xanthine oxidase | WAPHARM AB (SE) | 2003-07-29 | — | — | US | disclosed |
| EP-1007025-A1 | USE OF HYDROXYGUANIDINES | Wa Pharm AB (SE) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998023267-A1 | USE OF HYDROXYGUANIDINES | WAPHARM AB (SE) | 1998-06-04 | — | — | WO | disclosed |