Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596370 | 0.88 | PTPN5 (0.38) | PTPN1PTPN5 | |
| SCHEMBL7193463 | 0.87 | PTPN1 (0.46) | NR1H2NR1H3PTPN1RXRAPTPN5 | |
| SCHEMBL7200463 | 0.83 | PTPN1 (0.52) | NR1H2NR1H3PTPN1RXRA | |
| SCHEMBL5413494 | 0.83 | PTPN1 (0.40) | NR1H2NR1H3PTPN1RXRA | |
| SCHEMBL7193465 | 0.72 | PTPN1 (0.67) | NR1H2NR1H3PTPN1PTPN5 | |
| SCHEMBL5404860 | 0.72 | PTPN1 (0.51) | NR1H2NR1H3PTPN1PTPN5 | |
| SCHEMBL3735793 | 0.71 | PTPN1 (0.39) | PTPN1RXRAPTPN5 | |
| SCHEMBL7187493 | 0.70 | PTPN1 (0.37) | PTPN1PTPN5 | |
| SCHEMBL7596371 | 0.70 | PTPN1 (0.53) | PTPN1RXRA | |
| SCHEMBL5398157 | 0.70 | PTPN1 (0.37) | NR1H2PTPN1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |