Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 1.00 |
| ▸ | PRKCG | P05129 | 4/20 | 0.47 |
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | AKT2 | P31751 | 4/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.47 |
| ▸ | PRKX | P51817 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857776 | 1.00 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6857774 | 1.00 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6855184 | 0.85 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6855177 | 0.85 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6857504 | 0.85 | AKT1 (0.73) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6857574 | 0.78 | AKT1 (0.64) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6857576 | 0.78 | AKT1 (0.64) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6853481 | 0.78 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6853486 | 0.78 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD | |
| SCHEMBL6853489 | 0.78 | AKT1 (1.00) | AKT1PRKCGPRKACAAKT2PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |