Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6736474 | 0.82 | MEN1 (0.46) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL27559095 | 0.79 | AR (0.50) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL31440585 | 0.79 | MAPT (0.53) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL6738412 | 0.74 | MEN1 (0.46) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL25422142 | 0.74 | MAPT (0.48) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL27559091 | 0.73 | MEN1 (0.45) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL6179582 | 0.73 | CYP19A1 (0.61) | CYP19A1MEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL6660357 | 0.71 | MAPT (0.49) | CYP19A1MEN1KMT2AMAPTHTR1A | |
| SCHEMBL6738421 | 0.70 | CYP19A1 (0.44) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL9388459 | 0.70 | MEN1 (0.58) | CYP19A1MEN1KMT2AMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599942-B1 | Method of lowering LDL cholesterol and Lipoprotein a levels in mammals using such compounds | NOVARTIS AG (CH) | 2003-07-29 | — | — | US | disclosed |