Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 20/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 15/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 13/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074261 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6074265 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL27580823 | 0.94 | ADRB3 (0.89) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL27581187 | 0.91 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6073667 | 0.91 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6073664 | 0.91 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6074600 | 0.90 | ADRB3 (0.81) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6074603 | 0.90 | ADRB3 (0.81) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6074543 | 0.88 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B | |
| SCHEMBL6074538 | 0.88 | ADRB3 (1.00) | ADRB3ADRB2ADRB1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1455771-A | Cyclic amine phenyl Beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | claimed |
| CN-1455771-A | Cyclic amine phenyl Beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | disclosed |
| EP-1301482-A1 | CYCLIC AMINE PHENYL BETA-3 ADRENERGIC RECEPTOR AGONISTS | Wyeth (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002006232-A1 | CYCLIC AMINE PHENYL BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |