Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.40 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.38 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202871 | 1.00 | ACE (0.43) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL29402233 | 0.96 | ACE (0.41) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL29402083 | 0.96 | ACE (0.41) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL29405310 | 0.96 | ACE (0.41) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL30437433 | 0.96 | ACE (0.41) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL30438134 | 0.96 | ACE (0.41) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL929324 | 0.91 | PTGS1 (0.48) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL21134741 | 0.91 | ACE (0.55) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL16770231 | 0.91 | ACE (0.55) | ACEFOLH1PTGS1SLC7A11GSTK1 | |
| SCHEMBL30625400 | 0.91 | PTGS1 (0.48) | ACEFOLH1PTGS1SLC7A11GSTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589751-B2 | Antibody specific for homocystamide adducts, such as those formed by dehydrating homocysteine to homocysteine thiolactone and reaction this with a carrier such as low density lipoprotein (LDL) to form homocystamide-LDL adduct | MCW RESEARCH FOUNDATION | 2003-07-08 | — | — | US | disclosed |
| US-20020015968-A1 | IMMUNOLOGICAL DETECTION OF THE HOMOCYSTAMIDE ADDUCT AND A THIOLACTONE IMMUNOASSAY FOR ENDOGENEOUS HOMOCYSTEINE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-02-07 | — | — | US | disclosed |