Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.76 |
| ▸ | PGR | P06401 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.76 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.73 |
| ▸ | SHBG | P04278 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203303 | 1.00 | HIF1A (0.76) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL25854534 | 0.92 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685723 | 0.92 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685722 | 0.92 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL13044945 | 0.89 | HIF1A (0.81) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL12045184 | 0.89 | HIF1A (0.81) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685787 | 0.89 | HIF1A (0.81) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685788 | 0.89 | HIF1A (0.81) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL22872809 | 0.89 | HIF1A (0.81) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL7202988 | 0.89 | HIF1A (0.73) | HIF1APGRLMNASERPINA6AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610675-B1 | Identifying nontoxic therapeutically inactive metabolite of drug which elicits particular therapeutic response, converting inactive metabolite into activated structurally related drug species which cleaves in vivo to inactive metabolite | Bodor, Nicholas S. | 2003-08-26 | — | — | US | disclosed |
| EP-0334853-B1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR, Nicholas S. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4996335-A | Soft steroids having anti-inflammatory activity | Bodor, Nicholas S. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0334853-A4 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY. | BODOR NICHOLAS S | 1990-02-26 | — | — | EP | disclosed |
| EP-0334853-A1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR, Nicholas S. (US) | 1989-10-04 | — | — | EP | disclosed |
| WO-1989003390-A1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR NICHOLAS S (US) | 1989-04-20 | — | — | WO | disclosed |
| US-4710495-A | Soft steroids having anti-inflammatory activity | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-12-01 | — | — | US | disclosed |