Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 11/20 | 0.62 |
| ▸ | HTR1D | P28221 | 8/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7201475 | 0.87 | HTR1B (0.61) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7208529 | 0.86 | HTR1B (0.65) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7205447 | 0.86 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7202293 | 0.84 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7202248 | 0.84 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7208536 | 0.84 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8209086 | 0.82 | HTR1B (0.76) | HTR1BHTR1DHTR1AGABRPGABRD | |
| SCHEMBL8209088 | 0.82 | HTR1B (0.76) | HTR1BHTR1DHTR1AGABRPGABRD | |
| SCHEMBL7203991 | 0.82 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL7202990 | 0.82 | HTR1B (0.62) | HTR1BHTR1DHTR1ACHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |