Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.55 |
| ▸ | GSK3A | P49840 | 4/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 9/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093589 | 0.86 | GSK3B (0.74) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5100846 | 0.83 | GSK3B (0.65) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4401816 | 0.78 | GSK3B (0.77) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5092714 | 0.77 | GSK3B (0.75) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4401599 | 0.76 | GSK3B (0.85) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5100249 | 0.74 | GSK3B (0.64) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5089235 | 0.74 | GSK3B (0.76) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4393762 | 0.73 | GSK3B (0.72) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4393595 | 0.73 | GSK3B (0.74) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4404401 | 0.73 | GSK3B (0.65) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |