Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3074212 | 1.00 | — | — | |
| Bromide SCHEMBL1843806 | 1.00 | — | — | |
| Bromide SCHEMBL5667040 | 1.00 | — | — | |
| SCHEMBL1063077 | 0.97 | — | — | |
| SCHEMBL11191940 | 0.97 | — | — | |
| Sulfuric Acid SCHEMBL4408202 | 0.85 | CYP2D6 (0.54) | — | |
| Bromide SCHEMBL7532633 | 0.79 | — | — | |
| SCHEMBL232032 | 0.75 | — | — | |
| Iodide SCHEMBL31317516 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL31317509 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114379-A1 | Methods of treating or preventing cell, tissue, and organ damage using human myeloid progenitor inhibitory factor-1 (MPIF-1) | HUMAN GENOME SCIENCES, INC. | 2003-06-19 | — | — | US | disclosed |
| US-6495129-B1 | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) | HUMAN GENOME SCIENCES, INC. | 2002-12-17 | — | — | US | disclosed |
| WO-2001026676-A9 | METHODS OF TREATING OR PREVENTING CELL, TISSUE, AND ORGAN DAMAGE USING HUMAN MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | HUMAN GENOME SCIENCES INC (US) | 2002-11-07 | — | — | WO | disclosed |
| EP-1225911-A1 | METHODS OF TREATING OR PREVENTING CELL, TISSUE, AND ORGAN DAMAGE USING HUMAN MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | Human Genome Sciences (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026676-A1 | METHODS OF TREATING OR PREVENTING CELL, TISSUE, AND ORGAN DAMAGE USING HUMAN MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | HUMAN GENOME SCIENCES, INC. (US) | 2001-04-19 | — | — | WO | disclosed |