Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.53 |
| ▸ | HTR1B | P28222 | 13/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR1F | P30939 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203958 | 0.89 | HTR1D (0.55) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7208615 | 0.89 | HTR1D (0.53) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7205054 | 0.89 | HTR1D (0.53) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7202870 | 0.87 | HTR1D (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7202271 | 0.87 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7201088 | 0.87 | HTR1D (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7202941 | 0.85 | HTR1D (0.54) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7205055 | 0.85 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7205831 | 0.84 | HTR1D (0.53) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7204458 | 0.84 | HTR1D (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |