Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204947 | 0.96 | ADORA2A (0.45) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| SCHEMBL7211364 | 0.94 | ADORA2A (0.45) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7202131 | 0.93 | ADORA2A (0.47) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| Formic Acid SCHEMBL7204951 | 0.92 | ADORA2A (0.50) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| Formic Acid SCHEMBL7204946 | 0.92 | ADORA2A (0.50) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| SCHEMBL7207432 | 0.91 | ADORA2A (0.51) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| SCHEMBL7207428 | 0.91 | ADORA2A (0.51) | ADORA2ACDK1CDK2CCNE1CCNB2 | |
| SCHEMBL7211360 | 0.90 | ADORA2A (0.43) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7208455 | 0.90 | ADORA2A (0.39) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7202130 | 0.89 | ADORA2A (0.46) | ADORA2ACDK1CDK2CCNE1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-1056759-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041267-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |