Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 7/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947219 | 0.95 | EHMT2 (0.50) | HDAC6TNFEHMT2EHMT1KDR | |
| Hydrochloric Acid SCHEMBL6030719 | 0.90 | HDAC6 (0.51) | HDAC6TNFEHMT2EHMT1KDR | |
| SCHEMBL4386072 | 0.89 | TNF (0.49) | HDAC6TNFEHMT2EHMT1EGFR | |
| SCHEMBL5217336 | 0.89 | HDAC6 (0.47) | HDAC6TNFEHMT2EGFRKDR | |
| SCHEMBL6789011 | 0.88 | TNF (0.48) | HDAC6TNFEGFRKDR | |
| SCHEMBL5216522 | 0.86 | FGFR2 (0.48) | HDAC6TNFEGFR | |
| SCHEMBL664005 | 0.85 | HDAC6 (0.55) | HDAC6TNF | |
| SCHEMBL5562061 | 0.85 | HDAC6 (0.55) | HDAC6TNF | |
| SCHEMBL4371036 | 0.85 | HDAC6 (0.49) | HDAC6TNFEGFRKDR | |
| SCHEMBL5220322 | 0.85 | FGFR2 (0.49) | HDAC6TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |