Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205528 | 1.00 | CCR1 (0.49) | CCR1CHRM2CCR5KMT2AOPRD1 | |
| SCHEMBL10287667 | 0.89 | CCR1 (0.54) | CCR1CHRM2CCR5KMT2AOPRD1 | |
| SCHEMBL14580303 | 0.89 | CCR1 (0.48) | CCR1CHRM2CCR5OPRD1OPRM1 | |
| SCHEMBL10287860 | 0.87 | CCR1 (0.50) | CCR1CHRM2CCR5KMT2ATBXA2R | |
| SCHEMBL14420182 | 0.87 | CCR1 (0.50) | CCR1CHRM2CCR5KMT2ATBXA2R | |
| SCHEMBL13824391 | 0.85 | CCR1 (0.49) | CCR1CHRM2CCR5OPRD1TBXA2R | |
| SCHEMBL10287858 | 0.85 | CCR1 (0.49) | CCR1CHRM2CCR5OPRD1TBXA2R | |
| SCHEMBL12121518 | 0.85 | CCR1 (0.52) | CCR1CHRM2CCR5KMT2AOPRD1 | |
| SCHEMBL14419979 | 0.85 | CCR1 (0.52) | CCR1CHRM2CCR5KMT2AOPRD1 | |
| SCHEMBL12121529 | 0.85 | CCR1 (0.56) | CCR1CHRM2CCR5KMT2ATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-6613905-B1 | Treating or preventing a disease associated with aberrant leukocyte recruitment and/or activation | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-02 | — | — | US | disclosed |