Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815734 | 0.98 | MAPT (0.45) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL9613268 | 0.94 | MAPT (0.41) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL9033449 | 0.90 | NPSR1 (0.38) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL5640425 | 0.83 | KDM4E (0.39) | MAPTALDH1A1L3MBTL1NPSR1KMT2A | |
| SCHEMBL12049719 | 0.81 | CYP3A4 (0.38) | MAPTALDH1A1L3MBTL1NPSR1CYP3A4 | |
| SCHEMBL4187602 | 0.77 | CYP2C19 (0.35) | ALDH1A1 | |
| SCHEMBL5526779 | 0.77 | MAPT (0.51) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL12380772 | 0.77 | KMT2A (0.33) | MAPTALDH1A1NPSR1CYP3A4KMT2A | |
| SCHEMBL14393120 | 0.75 | MAPT (0.50) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| Hydrochloric Acid SCHEMBL5526775 | 0.75 | MAPT (0.50) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |