Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 7/20 | 0.35 |
| ▸ | KDM5A | P29375 | 7/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206262 | 1.00 | LSS (0.35) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7204707 | 0.98 | EPHX2 (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7204704 | 0.98 | EPHX2 (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7207162 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7207147 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7204746 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7204748 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7209643 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7209647 | 0.96 | LSS (0.36) | LSSKDM5AEPHX2KDM4CKDM5C | |
| SCHEMBL7207158 | 0.84 | EPHX2 (0.37) | LSSEPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |