Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 11/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7205560 | 0.99 | CHEK1 (0.52) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7206973 | 0.89 | CHEK1 (0.54) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7205355 | 0.89 | CHEK1 (0.54) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7209868 | 0.89 | EGFR (0.55) | CHEK1KDM1ASRCEGFRKDR | |
| Hydrochloric Acid SCHEMBL7211125 | 0.89 | CHEK1 (0.54) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL6371867 | 0.89 | CHEK1 (0.54) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7205019 | 0.88 | CHEK1 (0.58) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7211414 | 0.88 | CHEK1 (0.58) | CHEK1KDM1ASRCEGFRKDR | |
| SCHEMBL7207080 | 0.88 | CHEK1 (0.53) | CHEK1KDM1ASRCEGFRKDR | |
| Hydrochloric Acid SCHEMBL7211395 | 0.88 | CHEK1 (0.57) | CHEK1KDM1ASRCEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |