Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211368 | 0.87 | ABCG2 (0.43) | KDRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7210042 | 0.86 | ABCG2 (0.43) | KDRFGFR1FLT1 | |
| SCHEMBL7205641 | 0.84 | CHEK1 (0.50) | CHEK1ALDH1A1FGFR2KDREGFR | |
| SCHEMBL7210165 | 0.83 | CHEK1 (0.67) | CHEK1MAPTMAPK1ALDH1A1KDR | |
| SCHEMBL3942219 | 0.83 | CHEK1 (0.60) | CHEK1FGFR2KDREGFRILK | |
| Hydrochloric Acid SCHEMBL4498721 | 0.82 | KDR (0.46) | CHEK1HTTFGFR2KDREGFR | |
| Hydrochloric Acid SCHEMBL4513516 | 0.80 | CHEK1 (0.47) | CHEK1MAPK1ALDH1A1TDP1FGFR2 | |
| SCHEMBL3935762 | 0.80 | CHEK1 (0.58) | CHEK1FGFR2KDREGFRILK | |
| Hydrochloric Acid SCHEMBL4507765 | 0.76 | CHEK1 (0.49) | CHEK1HTTFGFR2KDREGFR | |
| SCHEMBL5272895 | 0.74 | CHEK1 (0.41) | CHEK1FGFR2KDREGFRILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |