Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.77 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210129 | 0.90 | CHEK1 (0.75) | CHEK1AURKAAURKBSRCFGFR1 | |
| SCHEMBL6372123 | 0.89 | CHEK1 (0.78) | CHEK1AURKAAURKBSRCFGFR1 | |
| Hydrochloric Acid SCHEMBL5499449 | 0.89 | CHEK1 (0.71) | CHEK1AURKAAURKBSRCFGFR1 | |
| SCHEMBL4510546 | 0.89 | CHEK1 (0.78) | CHEK1AURKAAURKBSRCSIGMAR1 | |
| Hydrochloric Acid SCHEMBL4504657 | 0.88 | CHEK1 (0.77) | CHEK1AURKAAURKBSRCFGFR1 | |
| Hydrochloric Acid SCHEMBL4518548 | 0.88 | CHEK1 (0.77) | CHEK1AURKAAURKBSRCSIGMAR1 | |
| Hydrochloric Acid SCHEMBL5499181 | 0.88 | CHEK1 (0.67) | CHEK1AURKAAURKBSRCFGFR1 | |
| SCHEMBL5280709 | 0.88 | CHEK1 (0.67) | CHEK1AURKAAURKBSRCFGFR1 | |
| Hydrochloric Acid SCHEMBL5498930 | 0.87 | CHEK1 (0.66) | CHEK1AURKAAURKBSRCFGFR1 | |
| SCHEMBL3939280 | 0.87 | CHEK1 (0.88) | CHEK1AURKAAURKBSRCSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |