SCHEMBL7206459

SCHEMBL7206459

CCNc1nc(N)c2nc(O)n(Cc3ccccc3)c2n1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TMIGD3 P0DMS9 10/20 0.54
ADORA2A P29274 10/20 0.54
ADORA1 P30542 10/20 0.54
ADORA2B P29275 8/20 0.54
TLR7 Q9NYK1 8/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208663 0.91 TMIGD3 (0.57) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7211508 0.90 ADORA2A (0.59) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL4474934 0.89 TLR7 (0.62) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7206499 0.88 TLR7 (0.47) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7210251 0.88 TLR7 (0.58) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7209428 0.87 ADORA2A (0.48) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7209368 0.87 TMIGD3 (0.48) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7207411 0.87 ADORA2A (0.61) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL2060224 0.87 ADORA2A (0.50) TMIGD3ADORA2AADORA1ADORA2BTLR7
SCHEMBL7205425 0.85 ADORA2A (0.69) TMIGD3ADORA2AADORA1ADORA2BTLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1035123-B1 NOVEL HETEROCYCLIC COMPOUNDS SUMITOMO PHARMA (JP) 2003-08-20 EP disclosed
US-6329381-B1 INTERFERONS, VIRICIDES AND ANTICARCINOGENIC AGENTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-12-11 US disclosed
EP-1035123-A1 NOVEL HETEROCYCLIC COMPOUNDS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2000-09-13 EP disclosed