Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | FPR3 | P25089 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209543 | 0.95 | HTR2C (0.56) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3272932 | 0.94 | HTR2C (0.55) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3266673 | 0.82 | HTR2C (0.61) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3270209 | 0.82 | HTR2C (0.52) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL25098488 | 0.80 | HTR2C (0.58) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL30620651 | 0.80 | HTR2C (0.58) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3274280 | 0.80 | HTR2C (0.59) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3267817 | 0.78 | HTR2C (0.66) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3272681 | 0.77 | HTR2C (0.65) | HTR2CHTR2AHTR2BHTR1ACHRM4 | |
| SCHEMBL3267894 | 0.77 | HTR2C (0.71) | HTR2CHTR2AHTR2BHTR1ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335907-A1 | PIPERAZINYLPYRAZINE COMPOUNDS AS AGONIST OR ANTAGONIST OF SEROTONIN 5HT-2 RECEPTOR | BIOVITRUM AB (SE) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002040456-A1 | PIPERAZINYLPYRAZINE COMPOUNDS AS AGONIST OR ANTAGONIST OF SEROTONIN 5HT-2 RECEPTOR | BIOVITRUM AB (SE) | 2002-05-23 | — | — | WO | disclosed |