Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.77 |
| ▸ | EDNRB | P24530 | 13/20 | 0.77 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | DHPS | P49366 | 1/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.58 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205231 | 0.94 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7206658 | 0.93 | EDNRA (0.67) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7205902 | 0.92 | EDNRA (0.65) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8326900 | 0.92 | EDNRA (0.82) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7206824 | 0.92 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7204657 | 0.91 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7205085 | 0.91 | EDNRA (0.73) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7210949 | 0.91 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7206042 | 0.90 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7209588 | 0.89 | EDNRA (0.62) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852226-B1 | PYRIMIDINE DERIVATIVES | KOWA CO (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-5883092-A | Pyrimidine derivatives as endothelin antagonists | KOWA CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| EP-0852226-A1 | PYRIMIDINE DERIVATIVES | KOWA CO. LTD. (JP) | 1998-07-08 | — | — | EP | disclosed |