Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732684 | 0.92 | PIK3CG (0.55) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607807 | 0.90 | PIK3CG (0.44) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5606912 | 0.86 | PIK3CD (0.47) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607359 | 0.85 | PIK3CD (0.44) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607509 | 0.85 | PIK3CD (0.56) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607070 | 0.85 | PIK3CD (0.48) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL27743795 | 0.84 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607745 | 0.83 | PIK3CD (0.43) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5608306 | 0.83 | PIK3CG (0.45) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL755175 | 0.82 | PIK3CG (0.54) | PIK3CGPIK3CDPIK3CBPIK3CAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278748-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081346-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |