Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16677157 | 0.93 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677774 | 0.93 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677816 | 0.93 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677223 | 0.91 | PIK3CD (0.61) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677362 | 0.91 | PIK3CD (0.61) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677518 | 0.91 | PIK3CD (0.61) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL358203 | 0.90 | PIK3CD (0.67) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677836 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677159 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG | |
| SCHEMBL16677823 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CBPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278748-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081346-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |