Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207921 | 0.80 | SLC6A4 (0.53) | SLC6A4HTR2ASLC6A2SCN9AKCNH2 | |
| SCHEMBL7207929 | 0.80 | SLC6A4 (0.53) | SLC6A4HTR2ASLC6A2SCN9AKCNH2 | |
| SCHEMBL6151217 | 0.76 | SLC6A4 (0.59) | SLC6A4HTR2ASLC6A2CYP2D6CYP2C19 | |
| SCHEMBL5878837 | 0.74 | SLC6A4 (0.83) | SLC6A4HTR2ASLC6A2KCNH2SLC6A3 | |
| SCHEMBL7207167 | 0.71 | SLC6A4 (0.69) | SLC6A4HTR2ASLC6A2KCNH2SLC6A3 | |
| SCHEMBL7065053 | 0.70 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL6151588 | 0.69 | SLC6A4 (0.55) | SLC6A4HTR2ASLC6A2CYP2D6CYP2C19 | |
| SCHEMBL7213331 | 0.67 | SLC6A4 (0.54) | SLC6A4HTR2ASLC6A2SCN9AKCNH2 | |
| SCHEMBL7065906 | 0.66 | SLC6A4 (0.65) | SLC6A4HTR2ASLC6A2SCN9AKCNH2 | |
| SCHEMBL5878711 | 0.65 | SLC6A4 (1.00) | SLC6A4HTR2ASLC6A2KCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610747-B2 | Such as 4-(2,3-dihydro-1-benzothien-5-yloxy)-3-((methylamino) methyl)-benzenesulfonamide for use as serotonin re-uptake inhibitors (SSRIs) in treatment of depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |