Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208094 | 1.00 | HDAC6 (0.55) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL1764578 | 0.92 | HDAC6 (0.58) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL1764581 | 0.92 | HDAC6 (0.58) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL27241012 | 0.92 | HDAC6 (0.58) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27241013 | 0.91 | HDAC6 (0.57) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31273762 | 0.91 | HDAC6 (0.57) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL7214248 | 0.85 | HDAC6 (0.68) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL7215029 | 0.85 | HDAC6 (0.60) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL7215034 | 0.85 | HDAC6 (0.60) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 | |
| SCHEMBL7864607 | 0.84 | HDAC6 (0.48) | HDAC6SLC15A1LMNATHRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617315-B1 | Sugar-substituted benzimidazole derivatives are used for the treatment or prophylaxis of restenosis, particularly following angioplasty | CHAMBERLAIN STANLEY DAWES (US) | 2003-09-09 | — | — | US | disclosed |
| US-6204249-B1 | L-benzimidazole nucleosides | GLAXO WELLCOME INC. | 2001-03-20 | — | — | US | disclosed |