Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718159 | 0.86 | PDE10A (0.47) | NPSR1PDE10ASLC6A3PDE4DTSHR | |
| SCHEMBL29615012 | 0.85 | PDE10A (0.49) | NPSR1PDE10ACHRM2CHRM4SLC6A3 | |
| SCHEMBL121762 | 0.85 | PDE10A (0.49) | NPSR1PDE10ACHRM2CHRM4SLC6A3 | |
| Hydrochloric Acid SCHEMBL28163034 | 0.84 | PDE10A (0.47) | NPSR1PDE10ACHRM2CHRM4SLC6A3 | |
| SCHEMBL718715 | 0.79 | TSHR (0.38) | NPSR1PDE10ASLC6A3PDE4DTSHR | |
| SCHEMBL719721 | 0.79 | PDE10A (0.41) | NPSR1PDE10ASLC6A3ALDH1A1HPGD | |
| SCHEMBL9423150 | 0.79 | CYP1A2 (0.47) | NPSR1CHRM4ALDH1A1TSHRMAPK1 | |
| SCHEMBL11903074 | 0.78 | NPSR1 (0.37) | NPSR1PDE10ASLC6A3PDE4DTSHR | |
| SCHEMBL11903077 | 0.78 | PDE10A (0.39) | NPSR1PDE10ASLC6A3PDE4DALDH1A1 | |
| SCHEMBL1610047 | 0.78 | PDE10A (0.49) | PDE10ACHRM2CHRM4PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2010092339-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | DPYD, DHODH, TYMP | NPSR1 3040/4885PDE10A 1953/4885CHRM2 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.