Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203902 | 0.94 | ADORA2A (0.65) | ADORA2AADORA2BADORA3ADORA1KDM4E | |
| SCHEMBL8091540 | 0.94 | ADORA2A (0.65) | ADORA2AADORA2BADORA3ADORA1KDM4E | |
| SCHEMBL7208875 | 0.92 | ADORA2A (0.58) | ADORA2AADORA2BADORA3ADORA1ALOX15 | |
| SCHEMBL7208873 | 0.90 | ADORA2A (0.56) | ADORA2AADORA2BADORA3ADORA1ALOX15 | |
| Trifluoroacetic Acid SCHEMBL7210128 | 0.89 | ADORA2A (0.49) | ADORA2AADORA2BADORA3ADORA1KDM4E | |
| SCHEMBL7203877 | 0.84 | ADORA2A (0.52) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7207888 | 0.81 | ADORA2A (0.49) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7203736 | 0.81 | ADORA2A (0.69) | ADORA2AADORA2BADORA3ADORA1 | |
| Trifluoroacetic Acid SCHEMBL7210014 | 0.79 | ADORA2A (0.57) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL10587027 | 0.77 | ADORA2A (0.82) | ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |