Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215417 | 0.89 | HDAC6 (0.56) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL10887379 | 0.87 | HDAC6 (0.70) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL10888099 | 0.87 | HDAC6 (0.67) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL7214896 | 0.86 | BCHE (0.57) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL7210529 | 0.84 | HDAC3 (0.51) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL7215477 | 0.83 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL6788161 | 0.81 | — | — | |
| SCHEMBL7215425 | 0.80 | HDAC3 (0.47) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL10886652 | 0.80 | HDAC6 (0.70) | HDAC6HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL10892687 | 0.80 | HDAC6 (0.70) | HDAC6HDAC3HDAC1HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335899-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | Actelion Pharmaceuticals Ltd. (CH) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038534-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-05-16 | — | — | WO | disclosed |